<p><em>This study aims to determine the effect of the use of information technology and employee knowledge on the effectiveness of accounting information systems in several shopping centers in Jember Regency. This type of research is a</em> <em>quantitative</em> <em>research. This research is based on primary data obtained from respondent’s answers by distributing questionnaires to users of accounting information systems at each shopping center in Jember Regency, such as cashiers, adm</em><em>in</em><em>s and other information system users. Sampling of data in this study using noprobability sampling technique with purposive sampling method. The number of respondents who became the sample of this study were 40 respondents. The analytical tehcnique used in this research is multiple linier regression, using SPSS version 22. The results of this study indicate that partially the use of information technology has a significant effect on the effectiveness of accounting information systems and employee knowledge has no significant effect on the effectiveness of accounting information systems.</em> <em>Simultaneously the use of information technology and employee knowledge affect the effectiveness of accounting information systems. It is hoped that further researchers can add data in the form of interviews from several respondents so that the data obtained are not only limited to the list of questions listed in the quesionnaires. </em></p>