<p><em>This research is meaningful to identify the impact of DER and DAR on ROA in the pharmaceutical manufacturing industry listed on the IDX in 2012-2020. The type of research used is a quantitative approach. The research population, namely the entire pharmaceutical sector of the Manufacturing Industry listed on the Indonesia Stock Exchange, is 12 industries, while the research sample is 5 pharmaceutical industries. The research result are convicing, 1) DER does no affect relevance to ROA, 2) DAR affect relevance to ROA, and 3) DER and DAR simultaneously have a positive effect on ROA.</em></p>